Sanctification pulls from Diablo 4 Items a curated pool of Diablo 4 Items powerful buffs, making it one of the most important gearing decisions in the season.

Possible buffs include:

1. Add a New Affix

This includes premium stats like:

+All Skills
Cooldown Reduction
Attack Speed
Resource generation
Damage reduction rolls

2. Add a Legendary Aspect

Even Uniques and Mythics can receive a bonus Aspect, creating hybrid gear with unprecedented power potential.

3. Affix Upgrade → Greater Affix

Upgrading an affix to a Greater Affix is among the most valuable rolls possible, often defining top-tier builds.

4. Replace an Existing Affix

This is the primary risk. You may lose a crucial affix (e.g., CDR, crit chance), so players should always be prepared.

5. Free Durability Removal

Minor but helpful for cheap Diablo 4 materials permanent gear.
PTR results show that affix replacement is a low probability, but D4 materials for sale still possible, making backup essential.